Clinical Lab Process Development Associate I- Cell Factory Full Time NEW

In support of continually changing initiatives, the Clinical Laboratory Process Development Associate I is committed to carrying out innovative, high-throughput lab processes and supporting the highest quality research to understand the impacts of genetic regulation on human health and disease. In this role, you are responsible for processing samples through a high throughput clinical research laboratory and meeting production goals.

In this position, you will complete multi-step processes for cell expansion, banking, perturbations, screens and working to develop cellular models of disease and biological processes of interest to researchers. In addition to standard production processes, this position will require individuals to participate in continuous improvement solutions through appropriate change management procedures and troubleshooting processes as needed.

The individual may be involved with the designing and executing of development, process improvement, or troubleshooting projects under direct guidance from the supervisor in support of platform goals and may be required to complete related training in JMP, Six Sigma, or other process improvement methods. Upon completion of these projects the individual is responsible for documenting and communicating results to others in the Platform during dedicated meetings. In addition, PDAs will assist with the general supervision of work of other laboratory personnel such as Process Development Technicians and Accessioning Technicians as required.

Job Responsibilities

• Maintain and optimize mammalian cell culture systems for screening experiments.
• Apply functional genomics techniques, including epigenomics, single-cell, transcriptomics, and CRISPR-based assays in human cells and tissues
• Follow standard operating procedures
• Each individual performs only those high complexity tests that are authorized by the Laboratory Director and require a degree of skill commensurate with the individual’s education, training, experience, and technical abilities.
• Tests will require the exercise of independent judgment and responsibility with minimal supervisor by the laboratory director or supervisor
• Adhere to the laboratory’s quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance performed.
• Follow the laboratory’s established policies and procedures whenever test systems are not within the laboratory’s established acceptable levels of performance.
• Be capable of identifying problems that may adversely affect test performance or reporting of test results. Correct the problems according to procedures or immediately notify the General Supervisor, Technical Supervisor, Clinical Consultant or Laboratory Director.
• Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications.
• Review and monitor quality metrics and communicate results to others in the Platform during dedicated meetings as needed.

Minimum Requirements

• BS/BA degree in Biology or Chemistry.
• 1+ years of relevant full time laboratory experience in this specialty subsequent to obtaining B.S./B.A. degree is required.
• Working, solid knowledge of basic aseptic / mammalian cell culture laboratory techniques required as a part of the above 1 year of experience.
• Strong analytical skills, problem solving ability, and innovation aptitude required.
• Recent (within the last year) laboratory experience with the use of standard cell lab equipment such as pipettes, centrifuges, biosafety cabinets, microscopes, gel electrophoresis required.
• Knowledge of high-throughput screening and automation and/or experience working in a high throughput production setting is desired, but not required
• Experience with genome editing tools including CRISPR targeting in various human cell types is preferred.
• Strong hands-on experience in molecular biology, genomics, and cellular biology (cell-based assays) is preferred.
• Familiarity with single cell sequencing methods preferred.
• Experience with iPSCs, cell line and/or primary cell culture preferred.
• Please attach your resume and a copy of your transcripts when applying to be considered.**

The Broad Institute will not offer visa sponsorship for this opportunity.

Pay Range: 58,000 – 76,667 Usd Annual

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.